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Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy

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Cancer-specific neoantigens created in the form of a covalent drug conjugated to a fragment of an intracellular oncoprotein selectively mark drug-resistant cancer cells for killing with bispecific T-cell engagers. Click to show full abstract

Cancer-specific neoantigens created in the form of a covalent drug conjugated to a fragment of an intracellular oncoprotein selectively mark drug-resistant cancer cells for killing with bispecific T-cell engagers.

Keywords: inhibitors targeted; neoantigens covalent; covalent inhibitors; mhc restricted; creating mhc; restricted neoantigens

Journal Title: Cancer Discovery
Year Published: 2022

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