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A new model for studying T-cell exhaustion in human cells has enabled scientists to discover a transcription factor that, when overexpressed, helps make chimeric antigen receptor T cells resistant to… Click to show full abstract
A new model for studying T-cell exhaustion in human cells has enabled scientists to discover a transcription factor that, when overexpressed, helps make chimeric antigen receptor T cells resistant to this mechanism of immune failure. A separate team has found that deleting a key phosphatase improved the antitumor function of engineered T cells as well.
Keywords:
cells counter;
generation car;
counter exhaustion;
next generation;
car cells;
exhaustion
Journal Title: Cancer discovery
Year Published: 2020
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Journal Title: Cancer discovery
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!