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In low-grade gliomas, mutant forms of IDH1/2 trigger expression of tau, a protein typically associated with neurodegenerative disease that also inhibits EGFR signaling to impede tumor progression. The new findings… Click to show full abstract
In low-grade gliomas, mutant forms of IDH1/2 trigger expression of tau, a protein typically associated with neurodegenerative disease that also inhibits EGFR signaling to impede tumor progression. The new findings provide a scientific rationale for pharmacologically mimicking the function of tau with microtubule-stabilizing drugs for the treatment of brain tumors.
Keywords:
protein;
protein suppresses;
alzheimer related;
suppresses gliomas;
related protein
Journal Title: Cancer discovery
Year Published: 2020
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Journal Title: Cancer discovery
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!