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T Cells Targeting MAGE-A4 Shrink Tumors.

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Autologous T cells engineered to target the MAGE-A4 cancer testis antigen successfully shrank a wide range of solid tumors with a manageable toxicity profile. In a phase I trial, the… Click to show full abstract

Autologous T cells engineered to target the MAGE-A4 cancer testis antigen successfully shrank a wide range of solid tumors with a manageable toxicity profile. In a phase I trial, the therapy, ADP-A2M4, showed the most promise in synovial sarcoma, yielding a disease control rate of around 90%.

Keywords: targeting mage; shrink tumors; mage shrink; mage; cells targeting

Journal Title: Cancer discovery
Year Published: 2020

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