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A major hurdle to the efficacy of adoptive cell therapy and chimeric antigen receptors T-cell therapy is the choice of antigen(s) to target. An article in this issue addresses this… Click to show full abstract
A major hurdle to the efficacy of adoptive cell therapy and chimeric antigen receptors T-cell therapy is the choice of antigen(s) to target. An article in this issue addresses this by capitalizing on the synergistic effect of pathogen-based immunotherapy and adoptive cell therapy that results in epitope/antigen spreading and enhancement of the endogenous T-cell response against antigens not originally targeted. See article by Xin et al., p. 7
Keywords:
tumor antigen;
antigen heterogeneity;
adoptive cell;
cell;
cell therapy
Journal Title: Cancer Immunology Research
Year Published: 2020
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2020
Link to full text (if available)
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recommendations!