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The authors show that tumor-specific T cells upregulate and require the transcriptional regulator BHLHE40 for tumor microenvironment remodeling and effective immune checkpoint therapy. BHLHE40 is a potential biomarker for immune… Click to show full abstract
The authors show that tumor-specific T cells upregulate and require the transcriptional regulator BHLHE40 for tumor microenvironment remodeling and effective immune checkpoint therapy. BHLHE40 is a potential biomarker for immune checkpoint therapy efficacy and possible therapeutic target.
Keywords:
bhlhe40;
tumor;
checkpoint therapy;
immune checkpoint
Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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recommendations!