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IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status

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An IDO-specific peptide vaccine is demonstrated to target IDO+ cells, enhancing vaccine-induced immune responses against non-IDO tumor antigens. These effects reduce tumor growth and inhibit immune-suppressive myeloid populations in multiple… Click to show full abstract

An IDO-specific peptide vaccine is demonstrated to target IDO+ cells, enhancing vaccine-induced immune responses against non-IDO tumor antigens. These effects reduce tumor growth and inhibit immune-suppressive myeloid populations in multiple tumor models.

Keywords: suppressive myeloid; tumor; myeloid populations; ido; immune suppressive; vaccine

Journal Title: Cancer Immunology Research
Year Published: 2022

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