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TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

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Myc-driven B-cell lymphoma is demonstrated to induce selective and early TCR-independent metabolic suppression of CD4+ T cells. This process precedes changes to T-cell fate and function and occurs before significant… Click to show full abstract

Myc-driven B-cell lymphoma is demonstrated to induce selective and early TCR-independent metabolic suppression of CD4+ T cells. This process precedes changes to T-cell fate and function and occurs before significant changes in tumor burden.

Keywords: independent metabolic; cell fate; changes cell; metabolic reprogramming; tcr independent

Journal Title: Cancer Immunology Research
Year Published: 2022

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