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Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers

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Engineered T lymphocytes secreting anti–CD19 T-cell engagers (STAb-T19) prevent the down-modulation of CD19 and result in rapid, efficient elimination of cancer cells by recruiting endogenous T cells, thus preventing CD19-positive… Click to show full abstract

Engineered T lymphocytes secreting anti–CD19 T-cell engagers (STAb-T19) prevent the down-modulation of CD19 and result in rapid, efficient elimination of cancer cells by recruiting endogenous T cells, thus preventing CD19-positive relapses associated with CD19-targeting CAR T-cell therapies.

Keywords: cd19 cell; cell; lymphocytes secreting; secreting anti; cd19; anti cd19

Journal Title: Cancer Immunology Research
Year Published: 2022

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