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The mechanisms underlying hyperprogressive disease (HPD) associated with PD-1 blockade are unclear. The authors develop a way to reproduce HPD by partially eliminating CD8+ T cells with NIR-PIT, creating a… Click to show full abstract
The mechanisms underlying hyperprogressive disease (HPD) associated with PD-1 blockade are unclear. The authors develop a way to reproduce HPD by partially eliminating CD8+ T cells with NIR-PIT, creating a regulatory T cell–dominant tumor microenvironment permissive of tumor growth.
Keywords:
dominant tumor;
tumor microenvironment;
tumor;
hyperprogressive disease
Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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recommendations!