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Extracellular adenosine in the tumor microenvironment can impair antitumor immunity by suppressing CTL responses. Inhibition of adenosine signaling stabilizes CTL–target cell conjugation and increases sublethal hit frequency, and thereby restores… Click to show full abstract
Extracellular adenosine in the tumor microenvironment can impair antitumor immunity by suppressing CTL responses. Inhibition of adenosine signaling stabilizes CTL–target cell conjugation and increases sublethal hit frequency, and thereby restores CTL-mediated cytotoxicity against antigenic melanoma tumors.
Keywords:
cytotoxicity;
adenosine a2a;
antagonism restores;
restores additive;
receptor antagonism;
a2a receptor
Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!