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Tissue-Resident Memory T Cells in Pancreatic Ductal Adenocarcinoma Coexpress PD-1 and TIGIT and Functional Inhibition Is Reversible by Dual Antibody Blockade

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Immunotherapy has had little success in PDAC. The authors report an in-depth investigation of the PDAC tumor microenvironment that highlights PD-1 and TIGIT, or their corresponding ligands, as potential targets… Click to show full abstract

Immunotherapy has had little success in PDAC. The authors report an in-depth investigation of the PDAC tumor microenvironment that highlights PD-1 and TIGIT, or their corresponding ligands, as potential targets for combinatorial therapy to treat this devastating disease.

Keywords: resident memory; tissue resident; ductal adenocarcinoma; pancreatic ductal; memory cells; cells pancreatic

Journal Title: Cancer Immunology Research
Year Published: 2023

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