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The authors show that subcapsular sinus macrophages promote aggressiveness of metastatic melanoma cells by releasing IL1α, which upregulates STAT3 signaling in the tumor. Blocking IL1α could synergize with STAT3 inhibitors… Click to show full abstract
The authors show that subcapsular sinus macrophages promote aggressiveness of metastatic melanoma cells by releasing IL1α, which upregulates STAT3 signaling in the tumor. Blocking IL1α could synergize with STAT3 inhibitors in treating metastatic melanoma.
Keywords:
promote melanoma;
subcapsular sinus;
il1;
macrophages promote;
sinus macrophages
Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!