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iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration

Immune-inflamed cancers can be responsive to immunotherapies; however, their granular characterization is challenging. iBRIDGE integrates and ‘bridges’ bulk and scRNA-seq datasets and can be used to identify cell-type specific markers… Click to show full abstract

Immune-inflamed cancers can be responsive to immunotherapies; however, their granular characterization is challenging. iBRIDGE integrates and ‘bridges’ bulk and scRNA-seq datasets and can be used to identify cell-type specific markers of immune-inflamed tumors in multiple tumor cohorts.

Keywords: cell; type specific; specific markers; inflamed tumors; markers immune; cell type

Journal Title: Cancer Immunology Research
Year Published: 2023

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