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Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

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Loss of nitric oxide synthase is shown to debilitate cytotoxic T cells in the therapeutic setting. Although nitric oxide is typically characterized as immunosuppressive, these data highlight its key intrinsic… Click to show full abstract

Loss of nitric oxide synthase is shown to debilitate cytotoxic T cells in the therapeutic setting. Although nitric oxide is typically characterized as immunosuppressive, these data highlight its key intrinsic role in modulating T-cell tumor infiltration and suppression.

Keywords: cell; infiltration tumors; nitric oxide; tumors regulated; regulated cell

Journal Title: Cancer Immunology Research
Year Published: 2022

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