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Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success?

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In this issue of Cancer Immunology Research, Ferris and colleagues demonstrate that type 1 conventional DC (cDC1) vaccines drive tumor rejection through direct antigen presentation, without the need of endogenous… Click to show full abstract

In this issue of Cancer Immunology Research, Ferris and colleagues demonstrate that type 1 conventional DC (cDC1) vaccines drive tumor rejection through direct antigen presentation, without the need of endogenous cDC1. This suggests that cDC1-based vaccines could represent an optimal strategy to induce antitumor immunity in patients. See related article by Ferris et al., (7).

Keywords: cdc1; cell presentation; direct cell; cancer; immunology

Journal Title: Cancer immunology research
Year Published: 2022

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