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Transcriptional profiling reveals that tumor-infiltrating lymphocytes (TILs) with low TCR affinity to a tumor-associated antigen exhibit progenitor-like phenotypes and increased quiescence, whereas higher affinity TCR TILs exhibit more cell division… Click to show full abstract
Transcriptional profiling reveals that tumor-infiltrating lymphocytes (TILs) with low TCR affinity to a tumor-associated antigen exhibit progenitor-like phenotypes and increased quiescence, whereas higher affinity TCR TILs exhibit more cell division and faster progression to T-cell exhaustion programs.
Keywords:
low tcr;
progenitor like;
infiltrating lymphocytes;
tumor infiltrating
Journal Title: Cancer Immunology Research
Year Published: 2023
Link to full text (if available)
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Journal Title: Cancer Immunology Research
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!