LAUSR

This year, the Nobel Prize in Physiology or Medicine has been awarded to David Julius and Ardem Patapoutian for their work on exploring the molecular basis for sensing heat, cold, and mechanical force. Though the research by the two Nobel Laureates is not at all dealing with the innate immune system, there are a number of common aspects involved. For instance, using receptors for sensing heat, cold, and touch will allow an organism to interact with its environment and alert if there is a dangerous situation. While the research of David Julius and Ardem Patapoutian addresses the exterior environment, the innate immune system is serving the same purpose inside an organism. Also, here, sensing heat is an essential parameter as already discovered by the Roman encyclopedist Aulus Cornelius Celsus more than 2,000 years ago. He identified an increase in the body temperature as one of the four cardinal signs of inflammation, which are, apart from calor (warmth), also dolor (pain), tumor (swelling), and rubor (redness) [1]. This issue of Journal of Innate Immunity is yet another example underlining that changes in temperature are of great importance in our fight against infectious diseases. For instance, the review article by Gabarin et al. [2] is addressing the role of intracellular and extracellular lipopolysaccharide signaling in sepsis. Notably, sepsis, a lifethreatening condition, is characterized by an increased body temperature [3], which is often a sign of systemic inflammatory reactions that can be caused, for instance, by a cytokine storm [4–6]. In addition to sepsis, also allergic reactions can influence the body temperature. In particular, eosinophils have been described in these processes [7]. In this issue, Luo et al. [8] illustrate that flagellin can alleviate airway allergic response by stabilizing eosinophils by modulating oxidative stress. Eosinophils have recently attracted considerable attention as, among many other functions, they can be used as biomarkers in chronic obstructive pulmonary disease [9] and are involved in adipose tissue inflammation [10]. Likewise, also viral infections can trigger many pathological immune responses, including fever. Odoardi et al. [11] report in their article, published in this issue, that IL27 has an important immunomodulatory role in Toll-like receptor 7 (TLR7) and TLR8 responses in viral infection. Though many other studies have shown that interleukins and TLRs are critical in evoking systemic inflammation in infectious diseases [12–14], the authors describe for the first time a prominent role for TLR8 in responding to ssRNA viruses and, therefore, they provide insight into how myeloid cell TLR-mediated responses are regulated during virus infection [11]. Another example is BAM15, a mitochondrial protonophore uncoupler, that was studied by Dang et al. [15]. Notably, mitochondrial uncouplers are involved in the thermoregulation and proton flux across membranes. Dang et al. [15] found in their study that Bam15 can attenuate inflammatory reaction in mice treated with the lipopolysaccharide.