LAUSR

The World Health Organization states that the application of pit and fissure sealants (PFS) is an effective way to prevent dental caries. Estimates of potential health and economic impacts of PFS upon school-age children provide crucial evidence to support the extension of PFS coverage to all target populations. The China Children's Oral Disease Comprehensive Intervention Project was launched in 2009 to provide free oral health examinations, PFS application, and oral health education for children aged seven to nine years. However, the national-level health and economic impacts of the program are unclear. To provide higher-quality evidence at the national level in China, we developed a multi-perspective, multi-state Markov model to estimate the cost and effect of PFS application to prevent dental caries. The total cost of the PFS project was 2.087 billion CNY, which can prevent 16.06 million PFMs from caries lesions. Compared with no intervention, PFS application was cost-effective from payer and society perspectives (BCR=1.22 from the payer's perspective, BCR=1.91 from the societal perspective). The incremental cost-effectiveness ratio (ICER) from both perspectives was negative (-61.46 CNY from the payer's perspective, and -125.75 CNY from the societal perspective), indicating that PFS was cost-effective and cost-saving. Expanding the coverage of PFS application in school can be a more cost-effective strategy for caries prevention in China.