LAUSR

We welcome the opportunity to respond to the question raised by El-Battrawy et al in their letter concerning our study entitled “The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.”1 In their letter, El-Battrawy et al state that the transmural differences observed in Hey2 +/− mice as compared with wild-type could be explained by the fact that the sodium current ( I Na) was measured at room temperature, whereas the transient outward potassium current ( I to) and action potential were evaluated at 36°C. The authors comment that sodium channel expression and sodium current density are modulated by temperature in Brugada Syndrome …