LAUSR

The coordinated expression of the ≈20 000 genes in the human genome is achieved by the concerted action of almost 1 million cis-regulatory regions.1 Many of these regions correspond to enhancers, controlling gene expression through long-range chromatin interactions that allow physical contacts between regulatory elements and their distant target genes. Each of these elements dictate aspects of the spatiotemporal expression of genes.2 The large disparity between the number of genes and regulatory elements in the human genome implies that genes may be regulated by an extensive network of regulatory elements, which is supported by evidence that individual promoters often engage with numerous distant regulatory regions.3