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Adjunctive and host directed therapies are increasingly recognised as an important target in the quest for novel effective antituberculous therapy.(1) The global increase in drug resistance to antibiotics suggests that… Click to show full abstract
Adjunctive and host directed therapies are increasingly recognised as an important target in the quest for novel effective antituberculous therapy.(1) The global increase in drug resistance to antibiotics suggests that effective adjunctive medications may provide an alternative avenue to treat infections. Vitamin D supplementation has been hypothesized as a potential adjunctive agent for the treatment of tuberculosis and evaluated in several trials.(2) Ganmaa and colleagues (2) evaluated the effectiveness of adjunctive vitamin D on sputum culture conversion and assessed the influence of key vitamin D pathway single nucleotide polymorphisms (SNPs) on sputum culture conversion concluding that there is no evidence that vitamin D supplementation improved outcomes.
Journal Title: American journal of respiratory and critical care medicine
Year Published: 2017
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