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Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization

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The human nasopharynx is frequently colonized by Streptococcus pneumoniae (the pneumococcus), serving as the reservoir for transmission, a state which necessarily precedes invasive pneumococcal infection. Influenza infection increases pneumococcal colonization… Click to show full abstract

The human nasopharynx is frequently colonized by Streptococcus pneumoniae (the pneumococcus), serving as the reservoir for transmission, a state which necessarily precedes invasive pneumococcal infection. Influenza infection increases pneumococcal colonization density and dysregulates host immune responses, increasing the risk of secondary bacterial pneumonia and death.

Keywords: two randomized; trials effect; colonization; pneumococcal colonization; effect live; randomized trials

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2019

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