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Smooth Muscle Cells: A Novel Site of P-Selectin Expression with Pathophysiological and Therapeutic Relevance in Pulmonary Hypertension

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World Symposium on Pulmonary Hypertension held in Nice in 2018, a change in the definition of PAH was proposed that would decrease the lower limit of mPAP to 20 mm… Click to show full abstract

World Symposium on Pulmonary Hypertension held in Nice in 2018, a change in the definition of PAH was proposed that would decrease the lower limit of mPAP to 20 mm Hg and a pulmonary vascular resistance. 3 WU; however, no conclusion was made regarding whether patients with an mPAP between 20 and 25 mm Hg should be treated (11). The ability to obtain an early diagnosis in PAH remains an important goal to be pursued. Sawada and colleagues have contributed to this quest by evaluating the performance of a large ECG-based screening program in healthy schoolchildren. Unfortunately, the studied screening program did not resolve this problem, and thus early diagnosis remains an important goal to pursue in children with PAH. n

Keywords: muscle cells; hypertension; smooth muscle; pulmonary hypertension; novel site; cells novel

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2019

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