LAUSR

dysregulated genes. Of note, ADRB2 gene activity is positively regulated by glucocorticoids. It is difficult to study how these two drug classes impact mechanisms, because both are central to asthma management. Therefore, other ways, including the use of mouse and cell culture models and clinical studies applying different doses of corticosteroids, need to be considered to determine how different doses influence gene expression. The challenge is to decide how best to take these findings forward. Now in its third funding period, SARP continues to show the enormous value and cost-effectiveness of large collaborative research studies to address questions in ways that could never be done by individual academic institutions or pharmaceutical companies. U-BIOPRED has been similarly productive. The findings from both consortia need to be validated, and cross-interrogation of the respective datasets would be of enormous value. We are now well into the era of asthma biologics, and a set of approved monoclonal antibodies that target different pathways is available. To understand how these drugs work on mechanisms, we need to use omics methods like the ones applied in this study. n