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Rhinovirus Infections in Individuals with Asthma Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19

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et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 2020;383:120–128. 9. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al.… Click to show full abstract

et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 2020;383:120–128. 9. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirusinduced lung injury. Nat Med 2005;11:875–879. 10. Brown NJ, Vaughan DE. Role of angiotensin ii in coagulation and fibrinolysis. Heart Fail Rev 1999;3:193–198. 11. Bain W, Li H, van der Geest R, Moore SR, Olonisakin TF, Ahn B, et al. Increased alternative complement pathway function and improved survival during critical illness. Am J Respir Crit Care Med 2020;202: 230–240. 12. Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, et al. Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. mBio 2018;9:e01753-18. 13. Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, et al.; CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis). High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med 2020;46:1089–1098.

Keywords: care; infections individuals; rhinovirus infections; asthma increase; med 2020; individuals asthma

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2020

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