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Reply to Thomson: Exposure to Active and Passive Tobacco Smoke on Urinary Eicosanoid Metabolites in Type 2 Asthma

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1. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, et al.; U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group. Urinary leukotriene E4 and prostaglandin… Click to show full abstract

1. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, et al.; U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group. Urinary leukotriene E4 and prostaglandin D2 metabolites increase in adult and childhood severe asthma characterized by type 2 inflammation: a clinical observational study. Am J Respir Crit Care Med 2021;203:37–53. 2. Thomson NC, Chaudhuri R, Spears M, Messow CM, Jelinsky S, Miele G, et al. Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy 2014;69:527–536. 3. Fauler J, Frölich JC. Cigarette smoking stimulates cysteinyl leukotriene production in man. Eur J Clin Invest 1997;27:43–47. 4. Gaki E, Papatheodorou G, Ischaki E, Grammenou V, Papa I, Loukides S. Leukotriene E(4) in urine in patients with asthma and COPD--the effect of smoking habit. Respir Med 2007;101:826–832. 5. Rabinovitch N, Reisdorph N, Silveira L, Gelfand EW. Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J Allergy Clin Immunol 2011;128:323–327. 6. Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, et al.; HiCARAT Investigators. Distinct phenotypes of smokers with fixed airflow limitation identified by cluster analysis of severe asthma. Ann Am Thorac Soc 2018;15:33–41.

Keywords: active passive; exposure active; reply thomson; tobacco smoke; thomson exposure; exposure

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2021

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