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Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma

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e PD, Donovan GM. Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and nonasthmatics. Am J Physiol Lung Cell Mol Physiol 2017;312:L425–L431. 7.… Click to show full abstract

e PD, Donovan GM. Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and nonasthmatics. Am J Physiol Lung Cell Mol Physiol 2017;312:L425–L431. 7. Brown RH, Togias A. Measurement of intraindividual airway tone heterogeneity and its importance in asthma. J Appl Physiol (1985) 2016; 121:223–232. 8. Lutchen KR, Jensen A, Atileh H, Kaczka DW, Israel E, Suki B, et al. Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med 2001;164: 207–215. 9. Tzeng YS, Lutchen K, Albert M. The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J Appl Physiol (1985) 2009;106:813–822. 10. James AL, Donovan GM, Green FHY, Mauad T, Abramson MJ, Cairncross A, et al. Heterogeneity of airway smooth muscle remodelling in asthma. Am J Respir Crit Care Med 2022;207:452–460. 11. de Lange EE, Altes TA, Patrie JT, Battiston JJ, Juersivich AP, Mugler JP III, et al. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 2009; 250:567–575. 12. Joseph C, Tatler AL. Pathobiology of airway remodeling in asthma: the emerging role of integrins. J Asthma Allergy 2022;15: 595–610. 13. Jamieson RR, Stasiak SE, Polio SR, Augspurg RD, McCormick CA, Ruberti JW, et al. Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity. J Appl Physiol (1985) 2021;130: 1635–1645. 14. Donovan GM, Elliot JG, Boser SR, Green FHY, James AL, Noble PB. Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment. J Appl Physiol (1985) 2019;126:599–606. 15. Hall CS, Quirk JD, Goss CW, Lew D, Kozlowski J, Thomen RP, et al. Single-session bronchial thermoplasty guided by Xe magnetic resonance imaging: a pilot randomized controlled clinical trial. Am J Respir Crit Care Med 2020;202:524–534.

Keywords: physiol 1985; heterogeneity; appl physiol; physiol; airway smooth; smooth muscle

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2022

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