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Moving the Dial on Airway Inflammation in Response to Trikafta in Adolescents with Cystic Fibrosis

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High insulin in early childhood is associated with subsequent asthma risk independent of body mass index. J Allergy Clin Immunol Pract 2022;10:785–792.e5. 5. Taussig LM, Wright AL, Holberg CJ, Halonen… Click to show full abstract

High insulin in early childhood is associated with subsequent asthma risk independent of body mass index. J Allergy Clin Immunol Pract 2022;10:785–792.e5. 5. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson children’s respiratory study: 1980 to present. J Allergy Clin Immunol 2003;111:661–675. [Quiz, p. 676.] 6. Ferreira SS, Nunes FPB, Casagrande FB, Martins JO. Insulin modulates cytokine release, collagen and mucus secretion in lung remodeling of allergic diabetic mice. Front Immunol 2017;8:633. 7. Proskocil BJ, Calco GN, Nie Z. Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats. Am J Physiol Lung Cell Mol Physiol 2021;320:L545–L556. 8. Nie Z, Proskocil B, Jacoby D, Fryer A. Potentiation effect of insulin on M3 muscarinic receptor agonist induced airway smooth muscle contraction. Eur Respir J 2019;54:PA4207. 9. HancoxRJ, Landhuis CE. Correlation betweenmeasures of insulin resistance in fasting and non-fasting blood.DiabetolMetabSyndr 2011;3:23

Keywords: moving dial; response trikafta; dial airway; airway inflammation; inflammation response; trikafta adolescents

Journal Title: American Journal of Respiratory and Critical Care Medicine
Year Published: 2023

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