LAUSR

of the initiation rate and the point in the titration curve in which propofol was started would be of interest for future analyses (2). We commend the authors for exploring a provocative and complex topic with a strong, multilayered statistical approach. The post hoc analyses should be interpreted prudently, but it is plausible the dose makes a difference in combination sedative therapy (12). Future work should factor heterogeneity of treatment effect for age into the trial design a priori and explore the pharmacokinetics–pharmacodynamic and safety profiles of sedative and analgesic combinations so commonly used in clinical practice (13–15).