LAUSR

Graves’ disease (GD), an autoimmune disorder resulting from thyrotropin (TSH) receptor stimulation by autoantibodies, is an uncommon disease in children. The incidence of GD is thought to be rising and is currently about 0.1 per 100,000 person-years in young children to 3 per 100,000 person-years in adolescents. The estimated prevalence varies between countries, from 1/10,000 in the United States to 1/100,000 person-years (for children aged 0–15 years) in the UK and Ireland. We reported one female patient, 14 years old, complained neck lump accompanied by exophthalmos, palpitation especially at night, followed by easily sweating all over her body. That manifestation also followed by increased of appetite, sleep disturbance, agitated, and behavioural changes those affecting her school report. Physical examination revealed hypertension, tachycardia, proptosis of both eyes, a non-pain palpable soft diffuse symmetrical mass on front neck followed down when swallowing, a systolic murmur, sweating on palms and soles of the feet. Laboratorium investigation was found FT4 >100,000 ng/dL (0.93-1.70); TSHs <0.05 IU/mL (0.27-4.20); T3 Total 28.6 nmol/L; TRAb 36.5 IU/L (≤1.75) and an ECG result found sinus tachycardia. Patient was treated with thyrozol (thiamazole) and propranolol. We need to increase awareness to adverse event of antihyperthyroid drugs, remission rate, predictor factors in successful treatment to get a better long-term outcomes of medical therapy in Grave’s disease.