LAUSR

The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed our basic understanding of the development and therapy of lung cancer. Yet, we have an incomplete understanding of the expressed kinases (kinome) in lung cancer progenitor cells and whether kinase expression and the overall kinome changes, or is reprogrammed, during transformation. We performed RNA-sequencing on freshly isolated human Alveolar Type II cells (ATII), Basal Cells (BC), and lung cancer cell lines to define the normal kinome in non-transformed cells and identify kinome changes during transformation. Our studies have identified a unique kinome for ATII and BC, and changes in their cells' respective kinome as they undergo transformation that identify potential therapeutic targets.   Keywords: alveolar type II cells, basal cells, kinases, kinome, lung adenocarcinoma, RNA-Sequencing, lung squamous cell carcinoma.