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ligands, the expectation is that they will only trigger G-protein–independent pathways that promote antiremodeling and bronchorelaxant actions via b -arrestin pathways that are distinct from those driving bronchial hyperresponsiveness. The… Click to show full abstract
ligands, the expectation is that they will only trigger G-protein–independent pathways that promote antiremodeling and bronchorelaxant actions via b -arrestin pathways that are distinct from those driving bronchial hyperresponsiveness. The study by Tompkins provides strong evidence for a therapeutic role of some of the M3 AChR-associated b -arrestin pathways that remain to be further investigated (?). GPCR=G-protein coupled receptor; GRKs=GPCR kinases; P=phosphorylation site; PLC=phospholipase.
Journal Title: American Journal of Respiratory Cell and Molecular Biology
Year Published: 2022
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