LAUSR

Pathogen-sized particles exhibit better performance in inducing immune responses than soluble protein antigens. However, engineering safe and efficient particulate carrier for antigens delivery remains a major challenge. In this study, self-assembly nanoparticles were prepared for antigens delivery based on the noncovalent interaction between α-cyclodextrin (α-CD) and polyethylene glycol (PEG). Inspired by the glycoprotein structure of viral envelope, the carrier was decorated with mannose on the surface. Meanwhile, α-CD/PEG provided a rigid core and the soluble protein antigens acted as corona to stabilize the assemblies. Consequently, nanoparticles enhanced the antigen internalization and presentation by antigen presenting cells (APCs), promoted the maturation and cytokines secretion of bone marrow derived dendritic cells in vitro, and stimulated higher expression of specific antibodies in vivo. These results indicate that self-assembly nanoparticle is a promising platform for antigen delivery.