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The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we… Click to show full abstract
The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.
Keywords:
glymphatic transport;
transport using;
using h217o;
transport;
direct imaging;
imaging glymphatic
Journal Title: JCI Insight
Year Published: 2021
Link to full text (if available)
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Journal Title: JCI Insight
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!