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Objective To determine the necessity for acid-washed containers for 24-h urine copper analysis. Methods Copper solutions, with concentrations relevant to clinical decision limits, were prepared by spiking both assay diluent… Click to show full abstract
Objective To determine the necessity for acid-washed containers for 24-h urine copper analysis. Methods Copper solutions, with concentrations relevant to clinical decision limits, were prepared by spiking both assay diluent and unknown urine samples with the copper calibrator. Samples were split between plain and acid-washed 24-h urine containers, and copper analysis was performed using inductively coupled mass spectrometry (ICP-MS). Results Measurement of copper in both spiked diluent and spiked urine samples showed minimal concentration bias between acid-washed and plain 24-h urine containers. Conclusions Acid-washed containers are not required for the measurement of copper in 24-h urine samples.
Journal Title: Annals of Clinical Biochemistry
Year Published: 2020
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