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A comparative analysis of the efficacy and safety of therapeutic interventions in phlegmasia cerulea dolens

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Objective Present an institution’s experience in management of phlegmasia cerulea dolens (PCD) with a review of the literature. Methods Beaumont Health’s electronic record database was queried between July 2009 and… Click to show full abstract

Objective Present an institution’s experience in management of phlegmasia cerulea dolens (PCD) with a review of the literature. Methods Beaumont Health’s electronic record database was queried between July 2009 and November 2019 for inpatients with PCD. A comprehensive chart review was performed to verify the accuracy of the diagnosis and extract relevant parameters. Medians and proportions are reported. Results 22 patients met the criteria for PCD. 59% females. Median age 65 years (interquartile range [IQR] 22). Obesity was present in 45% of patients. 18 patients underwent either a single modality (55.5%) or a multimodality therapeutic approach (44.5%). Limb amputation was required in a third of patients who underwent catheter-directed thrombolysis or percutaneous thrombectomy alone. Death was highest after percutaneous thrombectomy alone (66%) followed by pharmacomechanical catheter-directed thrombolysis alone (50%). Conclusion Percutaneous interventions have become the mainstay in management of PCD as demonstrated in this large retrospective analysis and supported by literature review.

Keywords: phlegmasia cerulea; cerulea dolens; comparative analysis; analysis efficacy

Journal Title: Phlebology
Year Published: 2020

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