LAUSR

Background Detecting renal allografts with impaired function early after renal transplantation and timely intervention are important to ensure a successful outcome. Purpose To detect impaired function of renal allografts at the early stage after renal transplantation using intravoxel incoherent motion imaging (IVIM). Material and Methods Forty-six recipients with good allograft function and 32 recipients with impaired function were included in this study. All participants were scanned with IVIM using 11 b-values on a 3-T magnetic resonance (MR) scanner; the apparent diffusion coefficient (ADC), ADC of slow diffusion (ADCslow), pseudo-diffusion (ADCfast), and perfusion fraction (f) values were calculated using a full bi-exponential model. Correlations between estimated glomerular filtration rate (eGFR) and the IVIM parameters were assessed by using Spearman correlation analysis. Receiver operating characteristics were used to assess the diagnostic utilities for detecting allografts with impaired function. Results The ADC, ADCslow, ADCfast, and f values of the renal cortex and the ADC and ADCslow values of the renal medulla were significantly higher in allografts with good function compared to those with impaired function (all P < 0.05). There was a significant corticomedullary difference in ADCslow, ADC, and f in all allografts. ADCfast values were higher in the cortex than in the medulla for allografts with good function but no differences were seen in allografts with impaired function (P > 0.05). Combined use of all cortical IVIM parameters has higher efficacy in detecting renal allograft dysfunction than any single parameter (sensitivity = 90.62%; specificity = 78.26%). Conclusion IVIM technique may be useful for detecting renal allograft dysfunction, especially combined use of cortical parameters.