LAUSR

This rhesus macaque was experimentally infected with Ebola virus, a zoonotic filovirus. Typical microscopic findings include hepatocellular degeneration and necrosis, fibrin deposition, hemorrhage, and variably sized, round-to-pleomorphic, eosinophilic, cytoplasmic inclusions consisting of aggregates of viral nucleocapsids. Immunofluorescence (green VP40, red VP35, and merged yellow, Image 2) indicates the high viral antigen expression during peak viremia. Machupo and Simian hemorrhagic fever viruses do not produce viral inclusions that are visible with routine staining. Although viral inclusions can occur with yellow fever (ie, Councilman bodies), this virus is asymptomatic in Old World monkeys, and extensive mortality is only observed in New World monkeys.