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Direct and flexible marginal inference for semicontinuous data

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The marginalized two-part (MTP) model for semicontinuous data proposed by Smith et al. provides direct inference for the effect of covariates on the marginal mean of positively continuous data with… Click to show full abstract

The marginalized two-part (MTP) model for semicontinuous data proposed by Smith et al. provides direct inference for the effect of covariates on the marginal mean of positively continuous data with zeros. This brief note addresses mischaracterizations of the MTP model by Gebregziabher et al. Additionally, the MTP model is extended to incorporate the three-parameter generalized gamma distribution, which takes many well-known distributions as special cases, including the Weibull, gamma, inverse gamma, and log-normal distributions.

Keywords: semicontinuous data; flexible marginal; direct flexible; mtp model; marginal inference; inference

Journal Title: Statistical Methods in Medical Research
Year Published: 2017

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