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Transendocardial CD34+ Cell Transplantation in Noncompaction Cardiomyopathy

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Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease… Click to show full abstract

Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34+ cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34+ cell therapy in a patient with noncompaction cardiomyopathy.

Keywords: cd34 cell; cell; cell transplantation; transendocardial cd34; noncompaction cardiomyopathy

Journal Title: Cell Transplantation
Year Published: 2018

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