LAUSR

The National Institute of Mental Health (NIMH) addressed in its 2008 Strategic Plan an emerging concern that the current diagnostic system was hampering translational research, as accumulating data suggested that the system’s disorder categories constituted heterogeneous syndromes rather than specific diseases. However, established practices in peer review placed high priority on that system’s disorders in evaluating grant applications for mental illness. To provide guidelines for alternative study designs, NIMH set a goal to develop new ways of studying psychopathology based on dimensions of measurable behavior and related neurobiological measures. The Research Domain Criteria (RDoC) project is the result, intended to build a literature that informs new conceptions of mental illness and future revisions to diagnostic manuals. The framework calls for the study of empirically derived fundamental dimensions characterized by related behavioral/psychological and neurobiological data (e.g., reward valuation, working memory). RDoC also emphasizes approaches including neurodevelopment, environmental effects, and the full range of dimensions of interest (from typical to increasingly abnormal), as well as research designs that integrate data across behavioral, biological, and self-report measures. This article provides an overview of the project’s first decade and its potential future directions. RDoC remains grounded in experimental psychopathology perspectives, and its progress is strongly linked to psychological measurement and integrative approaches to brain-behavior relationships.