LAUSR

Mathematical modeling is increasingly driving progress in clinical cognitive science and assessment. Mathematical modeling is essential for detecting certain effects of psychopathology through comprehensive understanding of telltale cognitive variables, such as workload capacity and efficiency in using capacity, as well as for quantitatively stipulating the subtle but important differences among these variables. The research paradigm guiding this formal clinical science is outlined. A distinctive cognitive abnormality in schizophrenia—taking longer to cognitively represent encountered stimulation—is used as a specific example to illustrate a general quantitative framework for studying intricate phenomena that impair mental health. Developments in mathematical modeling will also benefit symptom description and prediction; provide grounding in cognitive and statistical science for new methods of clinical assessment over time, both for individuals and for treatment regimens; and contribute to refining the cognitive-function side of clinical functional neurophysiology.