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The law of series is a phenomenon that pathologists frequently come across. It represents the observation that a rare diagnosis, once encountered, has the mysterious tendency of occurring again within… Click to show full abstract
The law of series is a phenomenon that pathologists frequently come across. It represents the observation that a rare diagnosis, once encountered, has the mysterious tendency of occurring again within a short time frame.1 We were faced with the law of series after observing bizarre multinucleated stromal giant cells in a fibroadenoma of a 19-year-old woman. Although a previous biopsy indicated a benign fibroepithelial lesion, the breast mass was excised because of its rapid enlargement. Macroscopic examination was inconspicuous and revealed a well-circumscribed round nodule measuring 42 mm. The microscopic evaluation showed a fibroepithelial lesion lacking leaf-like architecture and harboring a loosely arranged stroma with low cellularity and diffuse 914077 IJSXXX10.1177/1066896920914077International Journal of Surgical PathologySchoelinck et al research-article2020
Journal Title: International Journal of Surgical Pathology
Year Published: 2020
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