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Synthesis and fungicidal activity of novel ureido-substituted 1,3-benzoxazines

Ten novel ureido-substituted 1,3-benzoxazines were synthesized in moderate yields by La(OTf)3-catalyzed reaction of some aldehydes with four ureido-substituted 2-aminomethylphenols which were prepared by a one-pot method. Evaluation of their fungicidal… Click to show full abstract

Ten novel ureido-substituted 1,3-benzoxazines were synthesized in moderate yields by La(OTf)3-catalyzed reaction of some aldehydes with four ureido-substituted 2-aminomethylphenols which were prepared by a one-pot method. Evaluation of their fungicidal activity revealed that most compounds showed moderate to good activity and one of the ureido-substituted 2-aminomethylphenols showed activity against Rhizoctonia solani and Sclerotonia sclerotiorum comparable to the control compound, chlorothalonil.

Keywords: fungicidal activity; activity; novel ureido; ureido substituted; substituted benzoxazines

Journal Title: Journal of Chemical Research
Year Published: 2019

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