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By using PCl3 as the chlorinating reagent, various carboxylic acids are converted into the corresponding acid chlorides in good yields. This method features high atom efficiency in which nearly all… Click to show full abstract
By using PCl3 as the chlorinating reagent, various carboxylic acids are converted into the corresponding acid chlorides in good yields. This method features high atom efficiency in which nearly all three chlorine atoms of PCl3 are used in the chlorination. Moreover, the work-up procedure is simple since the major side product is phosphonic acid [HP(O)(OH)2] which is non-toxic and easily removed by filtration. A possible mechanism is proposed in this paper.
Keywords:
atom efficient;
chlorination;
efficient chlorination;
chlorination benzoic;
benzoic acids;
acids pcl3
Journal Title: Journal of Chemical Research
Year Published: 2019
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Journal Title: Journal of Chemical Research
Year Published: 2019
Link to full text (if available)
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recommendations!