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The preventive effect of abietic acid on skin cancer in mice was investigated in this study. Skin cancer mice model was caused by the combination of UVC and DMBA, and… Click to show full abstract
The preventive effect of abietic acid on skin cancer in mice was investigated in this study. Skin cancer mice model was caused by the combination of UVC and DMBA, and abietic acid was meanwhile intervened. The histopathology features of skin dyed HE staining and immunohistochemical staining were observed to explore tumor formation and skin morphological alteration, and MMP-1, MMP-3, CK10 and CK5/6 were examined. Abietic acid treatment had an obvious effect on experimental mice, and decreasing the expression of the above MMPs and CKs might be one of the possible mechanisms of the therapy.
Journal Title: Natural Product Communications
Year Published: 2017
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