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Hylomecon japonica (Thunb.) Prantl. is a Chinese medicinal plant whose active components and their antimicrobial mechanism was studied by TLC bioautography-guided isolation and identification of 12 alkaloids and their antimicrobial… Click to show full abstract
Hylomecon japonica (Thunb.) Prantl. is a Chinese medicinal plant whose active components and their antimicrobial mechanism was studied by TLC bioautography-guided isolation and identification of 12 alkaloids and their antimicrobial activities evaluated using the standard broth microdilution method. The benzophenanthridine isoquinoline alkaloids showed the strongest inhibitory activity against Gram-positive bacteria. Analysis of conductivity changes and observation of TEM images revealed that the antimicrobial mechanism involved cell integrity damage and cell division arrest.
Journal Title: Natural Product Communications
Year Published: 2017
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