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Biotransformation of Daidzein to Diadzein-7-Glucoside and Its Anti-allergic Activity

The biotransformation of daidzein and its diacetate was investigated using cultured plant cells of Phytolacca americana as biocatalysts. Daidzein was glucosylated to the corresponding 7-O-β-D-glucoside. On the other hand, daidzein… Click to show full abstract

The biotransformation of daidzein and its diacetate was investigated using cultured plant cells of Phytolacca americana as biocatalysts. Daidzein was glucosylated to the corresponding 7-O-β-D-glucoside. On the other hand, daidzein diacetate was hydrolyzed to daidzein, which was further glucosylated to 7-O-β-D-glucoside with much higher yield in comparison with the biotransformation of daidzein. Daidzein 7-O-β-D-glucoside showed higher inhibitory activity for histamine release from rat peritoneal mast cells than daidzein.

Keywords: diadzein glucoside; daidzein diadzein; biotransformation daidzein; daidzein; activity

Journal Title: Natural Product Communications
Year Published: 2017

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