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On the Structure of (R)-2-Methylheptyl Isonicotinate: Evidence for the Structural Solution from Total Synthesis

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The controversial molecular identification of (R)-2-methylheptyl isonicotinate (1) has been settled. Despite its significance as a potent anti-microbial agent against several clinically relevant pathogens, the structure of natural product is… Click to show full abstract

The controversial molecular identification of (R)-2-methylheptyl isonicotinate (1) has been settled. Despite its significance as a potent anti-microbial agent against several clinically relevant pathogens, the structure of natural product is uncertain so far due to controversial reports. Its structure has been resolved as bis (2-ethylhexyl) phthalate (2) by total syntheses of chain isomers. In addition, we have also revised bis (2-methylheptyl) phthalate (3) as (2) in some reports.

Keywords: structure methylheptyl; methylheptyl isonicotinate; structure; isonicotinate evidence; evidence structural

Journal Title: Natural Product Communications
Year Published: 2018

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